Glutathione — 1500 mg

Glutathione is a small endogenous peptide composed of glutamate, cysteine and glycine. Umbrella Labs identifies its product as the reduced form, GSH, and describes it in connection with intracellular antioxidant defenses and detoxification reactions. The reduced-versus-oxidized distinction is relevant because studies of glutathione biology often assess both the size of the available glutathione pool and its redox state, rather than treating all measurements as the same outcome.

In a six-month randomized, placebo-controlled study of fifty-four nonsmoking adults, Richie and colleagues investigated oral glutathione and reported increases in glutathione measured in several blood and cellular compartments. They also reported changes in an oxidative-stress ratio and, in a subset of participants, natural-killer-cell activity. Levels generally moved back toward baseline after supplementation ended. These findings explain research interest in antioxidant status and immune-related biomarkers, but they concern the oral preparation and endpoints studied rather than demonstrating the behavior of every vial format. The seller’s broader description is therefore best understood as positioning GSH for redox and cellular-defense research. It should remain chemically distinct from oxidized glutathione, glutathione precursors and branded mixtures that include other antioxidants.